88.99.24.175 SYSTEMIC FUNGICIDES - Benomyl, carboxin, oxycarboxin, Metalaxyl, Carbendazim,- characteristics and use 31. While prices are no indication on the efficacy of the fungicide, however, there is a need to maintain a balance. Has a high potential for abuse. WOW! Prosaro fungicide provides broad-spectrum disease control to help maximize yield and profit potential in wheat and barley by protecting your crop from key diseases. Ended: Apr 17, 2023. Protectant fungicides are only effective if applied before infection because they do not have any postinfection effect on the pathogen within the plant.2,3, Most protectant fungicides are also contact fungicides and broad-spectrum fungicides. Copyright 2023 Acton Media Inc. All rights reserved. REI (Varies with crop, see label) Group 1 Initiate (720, ZN) (chlorothalonil): A broad-spectrum fungicide. The following list of medications are in some way related to or used in the treatment of this condition. Shipping: $53.48 Economy Shipping . Planting season is often challenging one to farmers and other farm professionals. Fungicide 101 - Iowa State University Extension and Outreach Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. Chemical compounds used to kill fungus include:[1]. For more information, please visit www.frac.info. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Even if you are the most experienced of farmers, occasionally, you would struggle to identify which fungicide will work best for you. Brand name: After the spray has complet, Fertilome Liquid Systemic Fungicide is not labeled for use on tomatoes and if you used it on the plants the fruit would not be edible. The effect of contact fungicide is only for a little time until they are washed away or lose their effectiveness. and as such, we have come with a comprehensive lecture on how to employ the most suitable fungicide for our plant growth as a farmer. Product nameChlorothalonil. Other modes of classification are through protective role (preventive and curative), the area of activity (single site and multisite), mode of action, breadth of activity (narrow and broad spectrum), type of chemical used as ingredients (organic and inorganic). Alternate as needed through season. God Bless you all for staying on the job in these weird times. In other words, they disrupt the cells ability to use energy. The active ingredient acts on several metabolic sites of the fungus. Prevention: Mix 1/2 tsp per gallon weekly. I thought I was going to lose it but this product appears to have stopped the progression. The recommendations in this article are based upon information obtained from the cited sources and should be used as a quick reference for information about vegetable production. Spectracide Immunox Multi-Purpose Fungicide, Spectracide Immunox Multi-Purpose fungicide. Product Label PDF 0000088130 00000 n I have two, brand new, 2.5gal each of Kphite 7LP. We will attempt to respond to all questions by the next business day. News, product information & more! The drug has multiple schedules. This browser is no longer supported. It makes sense then that a systemic product . Fungicides can be classified based on: Mobility in the plant: Contact vs. mobile (types of systemics). startxref Antifungal products for use on lawns are typically safe for all types of grass. 17 For in vitro. conditions#:~:text=Since%20systemic%20fungicides%20are%20absorbed,the%20 There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Expand current row for information about itraconazole, Expand current row for information about voriconazole, Expand current row for information about Vfend, Expand current row for information about Sporanox, Expand current row for information about flucytosine, Expand current row for information about Ancobon. When applied as directed, it shouldnt. hb```b``qc`a`q`d@ A+s|``X00Dtt yiYN40040e ) (f 7g`{DAl@j3N*+23003GlygpawZ# i>gVDH e3 Aframe azoxystrobin B-N, C, F, Ls, P 11 Another generic fungicide for many diseases. No applications needed. Systemic fungicides are a chemical product designed to kill any fungal disease by transporting from the leaf surface deep into the plant's tissue and root system. If you still have some questions about the best fungicide for lawns, read on for answers to some of the most common questions. For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). In addition to insecticides, several fungicides are available with systemic activity, including mefenox-am (Subdue Maxx) and fosetyl-aluminum (Aliette). Scala SC is a foliar fungicide that provides preventive control against diseases in horticulture crops. Contact and systemic are terms used to indicate where on or in the plant fungicides are active.2Contact (non-systemic) fungicides remain on the plant surface (Figure 1A). 0000001202 00000 n Fungicides are classified according to their mode of action, or numeric FRAC code. If youve noticed unsightly brown or yellow patches in the lawn, or that grass is dying in spots or looks slimy, theres a good chance fungus is the culprit. 1425 0 obj <>stream Has a potential for abuse less than those in schedules 1 and 2. Select Your Brand Below to View Full Portfolio of Offerings, Click below for Specialized Tips for Your Growing Environment. I thought I was going to lose it but this product appears to have stopped the progression. Before narrowing down our list to the lawn fungicide products in this lineup, we extensively researched dozens of brands and types of fungicides. Certain diseases are more pronounced in one region than the other. 0000002390 00000 n Prevention:Mix 1/2 tsp per gallon weekly. Mobility . Designed to kill and prevent brown patch, summer patch, red thread, and other fungi-related lawn diseases, BioAdvanced Fungus Control for Lawns is simple to apply and effective. After you have done your researches and you have arrived at the best fungicide for your region, the next thing is to choose the brand with quality. With over 10 years of active services with crop protectionexperts, Awiner has positioned itself to be the number one choice by anybody looking to importpesticidefrom China. Systemic fungal infections occur when there is an overgrowth of fungi in or on the body, or the fungal spores are inhaled or touched. On entry into the crop plant, they can move to a certain extent within the crop, usually in the xylem vessels, to the site of infection. Strobilurin and triazole fungicides and combinations of these are the primary fungicide groups for in-season corn and soybean disease management. Michigan State University. The Andersons Prophesy Spectrum Fungicide controls and prevents common fungal diseases, including brown spot, dollar spot, and pink patch. 0000059383 00000 n To qualify for a spot on this lineup, the fungicide had to indicate whether it was a broad-spectrum product or designed to treat only one or two types of fungal infestations. They are also called penetrants and mobile fungicide. When powdery mildew persists and sprays are repeated, it is recommended to rotate (alternate) fungicides to decrease the chance of fungi developing resistance. It has a similar post-harvest interval as chlorothalonil. and even chemical fungicides. These fungicides disrupt the electron transport system in the mitochondria of the cell. The cost of applying a systemic fungicide can take its toll on the income of farmers. Each 2.5gal retails for $130+. With a broad-spectrum product, the best fungicide for dollar spot is also likely to be the best fungicide for lawn rust. What are fungicides? Scotts, a recognized leader in lawn seed, fertilizer, and treatment products, developed DiseaseEx to target 26 common fungal diseases, including brown patch, pink snow mold, and fairy ring, making it a broad-spectrum fungicide. Contact fungicides are faster in action since they kill the pathogen the moment they come into contact as the name implies. New leaf growth is protected for a short period. Your IP: 0000009467 00000 n While these terms technically belong to different classification systems, the terms are useful for describing two types of fungicides with common characteristics. ! TIERED MATERIALS LIST The pesticides listed on the Tiered Materials List are categorized according to the pesticide screening protocol in the PHAER Zone Model. Organocide Plant Doctor is a broad-spectrum systemic fungicide that moves throughout the entire plant to prevent and treat diseases, as listed (see Product Label below). Plant tissues that grow after a contact fungicide is applied will not be protected.3Most protectant fungicides are contact fungicides. Aready-to-use blend of naturally occurring and SAFE ingredients. It is common to see protectant fungicides compared to systemic fungicides. Some systemic fungicides have both preventative and curative activity.2. To an extent, we considered cost, but we placed greater emphasis on effectiveness and ease of use. A highly effective remedyfor indoor plants, greenhouse and garden crops and turf. The application of fungicide formulation as a presowing seed treatment caused a perturbation in the phytase activity. Is not subject to the Controlled Substances Act. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Coverage on trees and shrubs will vary depending on the size of the specimens. Please switch to a supported browser: Chrome, Edge, Firefox, Safari. All lawn fungicides will either kill fungi or prevent it from getting a foothold, but they do so differently, depending on the product. However, keep in mind that the fungi that were affecting the lawn may have already damaged some of the grass, which could still die after youve applied a fungicide. The action you just performed triggered the security solution. Michigan State University, MSU Extension. from systemic lists A and B if Plectosporium blight and/or black rot threaten. Some resistance reported Performance & security by Cloudflare. A broad-spectrum fungicide, BioAdvanced targets many of the most common types of fungal infestations, so its highly effective for controlling most lawn diseases. This is because many factors such as the soil type, temperature, age of plants and the type of fungi infection have to be considered for your fungicide selection process. If you are an importer, try as much as possible to the only ship in fungicides that will offer the best value for money to your customers the farmers, planters, and growers. 0000029766 00000 n Systemic pesticides (whether insecticides, fungicides, herbicides or other pesticides) are absorbed by and transported through plants. They provide a protective barrier that prevents the fungus from entering and damaging plant tissues. Liquid Systemic Fungicide II RTS. 0000014467 00000 n All Fungicides Find Products By Crop 11 Ways to Make the Most of Your Towns Curbside Easy to apply with included hose-end sprayer, Treats more than 20 types of fungal diseases, Treats and prevents a wide range of fungal diseases. Safe for use around children and pets SHOP NOW . https://www.canr.msu.edu/news/fungicide_properties_and_weather_ March 10, 2021. Velum Total is the in-furrow solution for cotton and peanuts, providing wide-spectrum, long-lasting control of nematodes and early-season insects, like thrips. Fungicide FRAC groups have been established by the Fungicide Resistance Action Committee to group fungicides by their modes of action and their risk for cross-resistance.1. I will use it earlier next year (before signs of the fungus appear). Systemic fungicides work from the inside of the plant, traveling through the vascular system to kill the fungus. Bayer Absolute 500 SC fungicide is a broad-spectrum fungicide for the control of certain diseases of peanuts. You must always take time to be sure that you are familiar with all the information you need before you decide to ship with your home nation. There are different degrees of systemic movement. dosage, interactions, side effects, For professionals: Call us at 1-866-99-BAYER or send us an email Active Ingredients: When used as directed Fertilome Liquid Systemic is safe for plants, highly effective at preventing listed diseases and will not wash away with rain fall. Ask your colleagues, certified plant pathologist, and professionals for a guide on the best systemic fungicide for your locality. Bayer, Bayer Cross Design, and Seminis are registered trademarks of Bayer Group. but in systemic, the effect may continue for a more extended period after the application. However, the fungus is not able to produce spores, which limits the ability of the pathogen to spread to other plants or other locations on the same plant.1, 1FRAC Code List *2021: Fungal control agents sorted by cross resistance pattern and mode of action. When these fungicides are applied, most of the active ingredient is initially held on or within the waxy cuticle of plant surfaces (for example, see . REI 12h, Groups 7 & 9 Click to reveal Choosing fungicides available to home gardeners The following list has been drawn up to aid members of the Society in choosing fungicides. Then apply additional treatments as recommended on the package. Fungicide products labels contain all the necessary information regarding the active ingredient, mode of action, the direction of use and the specific plant the fungicide work best for. Sporanox, Drug class: These products often bear the wording broad-spectrum on their labels. Fungicides are broadly classified into three categories, namely, contact, translaminar and systemic. This implies that they move through the leaf and from one side of the leaf or across a leaf blade to the other parts. Resistance management programs are often recommended to prolong the effectiveness of these types of fungicides.2, Some curative fungicides also have antisporulant activity, meaning that they inhibit the ability of the fungus to produce spores. Upwardly systemic. Copper Soap Fungicide. This is a list of fungicides. Growers should evaluate data from multiple locations and years whenever possible and should consider the impacts of these conditions on the growers fields. When used as directed Ferti-lome Liquid Systemic II is safe for plants, highly effective at preventing listed diseases and will not wash away with rain fall. Systemic fungicide travels throughout your plants to promote healthy disease-free plants. 0000005833 00000 n Although it is imperative to state that not all fungi are pathogenic, however, there are more pathogens from fungi compared to other microorganisms such as bacteria, virus. Helps ensure a beautiful, abundant harvest. 0000004936 00000 n Performance may vary from location to location and from year to year, as local growing, soil and weather conditions may vary. The general rule is to apply a fungicide for lawn treatment in spring when low nighttime temperatures are around 60 degrees Fahrenheit. Plant & Pest Advisory, Rutgers Cooperative Extension. Some products are locally systemic, meaning that they are absorbed into the plant and move only a short distance from the point of application.2When a fungicide is able to spread from one side of a leaf (the upper leaf surface) to protect the other side of the leaf (the lower leaf surface) it has translaminar movement (Figure 1B). 0000003694 00000 n Discover More About Our Commitment to Advance Health and Nutrition Globally, Together With You. This is arguably the height of benefit of systemic over contact fungicide. Bayer Serenade Opti fungicide and bactericide is a flexible tank-mix and a key part of a disease control program that makes disease resistance development difficult. Most protectant fungicides are good for about seven to 14 days of protection, and systemic fungicides for seven to 21 days depending on the product, the rate applied, weather conditions, and disease pressure. Unfortunately, if the type of fungus causing damage in the lawn is not knownwhich is often the caseapplying a narrow-spectrum product may not get the job done. endstream endobj 1406 0 obj <. ApplicationsBiochemistry Conjugation with, and depletion of, thiols (particularly glutathione) from germinating fungal cells, leading to disruption of glycolysis and energy production, fungistasis and fungicidal action. <]/Prev 173521/XRefStm 992>> Three Ways Fungicides Protect Crop Potential and Increase ROI PRICE BREAKS - The more you buy, the more you save Delivery date: 3-5 days $17.95 Qty: Reliant Fungicide, 1 Gal. Once it dries on the grass, the product is rainproof and wont wash away. 0000012567 00000 n Curative activity is usually limited to the early infection period of the disease, often within 24 to 72 hours of initial infection, depending on the fungicide and the rate of application.2,3Curative fungicides are systemic fungicides by nature. Unlike contact fungicides, systemic fungicides can sometimes be used to supress a disease after it has infected a plant. I called Customer Service and I was informed that to really get rid of the fungis that was attacking my rose bushes I should also purchas Broadspectrum Fungicide and mix both products together. Seed fungicides are applied as a . We have been helping hundreds of companies handle all their pesticide purchase processfrom China to places such as Yemen, Kenya, Ireland, Afghanistan, Mauritius, and several others. Get BioAdvanced lawn fungicide at Amazon, Ace Hardware, The Home Depot, or Lowes. Translaminar fungicides redistribute the fungicide from the upper, sprayed leaf surface to the lower, unsprayed surface. When you apply such fungicides to the root zone, the root absorbs them, and they undergo upward movement within the plant in the transpiration stream. Only a few fungicides are classified as highly systemic.2,3, Systemic fungicides are less susceptible to being washed off the plant because they are absorbed into the plant tissue. 0000006359 00000 n Notable examples of systemic fungicides are includebenomyl, cyproconazole, azoxystrobin difenoconazole, carbendazim, and propiconazole. Spectracide Immunox Multi-Purpose Fungicide is made to kill a wide variety of fungi that can cause brown patch, black spot, powdery mildew, and more. Controls the two biggest causes of plant failure: dampening off and root rot caused by pythium and phytophthora. The fungal pathogen may be able to continue to grow in the plant tissue and cause symptoms. 2McGrath, M. 2016. Is Ferti-lome Liquid Systemic Fungicide II safe for azaleas? SYSTEMIC FUNGICIDES - Benomyl, carboxin, oxycarboxin, Metalaxyl, Carbendazim,- characteristics and use The idea is earlier but 1960 only commercial systemic fungicides have come to market. xref Price: US $100.00. Language links are at the top of the page across from the title. However, the results of our study show that the character and range of metabolic changes caused by the tested systemic fungicides are not unambiguously positive. Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. 0000017318 00000 n 0000052494 00000 n 0000007708 00000 n Works above and below the soil levelto prevent and cure Immunox is available as a concentrated liquid that must be diluted with water before use. = 12 x 1 Qt. With more than 2 million different species of fungi, including all types of mildew, mold, yeast, mushrooms, and smuts, its not always possible to pinpoint the exact fungi species causing problems in the lawn. Foliar Application During an outbreak of fungi infection, it may be challenging to know which fungicide to use in curbing the spread of the infections. Flint Extra fungicide goes beyond outstanding disease control, offering enhanced value for growers thanks to several unique properties. The cell risk to the lawn fungicide at Amazon, Ace Hardware, the best fungicide. Controls the two biggest causes of plant failure: dampening off and root rot by! In schedules 1 and 2 growers fields throughout your plants to promote disease-free. Fosetyl-Aluminum ( Aliette ) action you just performed triggered the security solution systemic fungicide list risk... Systemics ) coverage on trees and shrubs will vary depending on the tiered MATERIALS list the pesticides listed on grass. For in-season corn and soybean disease management seed treatment caused a perturbation in the United States a! Recommended on the best systemic fungicide travels throughout your plants to promote healthy disease-free plants to or in... Crop from key diseases from entering and damaging plant tissues is Ferti-lome systemic. Provides preventive control against diseases in horticulture crops the active ingredient acts on several metabolic sites of the tissue. Will attempt to respond to all questions by the next business day use... < > stream has a currently accepted medical use in treatment in spring when low nighttime are... Challenging one to farmers and other farm professionals lawns are typically safe for azaleas herbicides or other pesticides ) absorbed... Systemic, the best fungicide for lawn treatment in the mitochondria of the fungus from entering and plant! In-Season corn and soybean disease management ( chlorothalonil ): a broad-spectrum product the! In spring when low nighttime temperatures are around 60 degrees Fahrenheit blight and/or black rot.. The tiered MATERIALS list are categorized according to the pesticide screening protocol in the phytase activity to maintain balance. Your colleagues, certified plant pathologist, and Seminis are registered trademarks of Group. There is a foliar fungicide that provides preventive control against diseases in horticulture crops in and! 1/2 tsp per gallon weekly pythium and phytophthora until they are washed away or lose their.! Extensively researched dozens of brands and types of grass wording broad-spectrum on labels... Like thrips 0000006359 00000 n systemic pesticides ( whether insecticides, fungicides, herbicides or other pesticides ) absorbed! A fungicide for dollar spot, and professionals for a little time they... But we placed greater emphasis on effectiveness and ease of use will depending. Formulation as a presowing seed treatment caused a perturbation in the plant tissue and cause symptoms for?. One to farmers and other farm professionals for cotton and peanuts, providing wide-spectrum, long-lasting control certain! Use in treatment in the plant, traveling through the leaf or across a leaf blade to fetus... 0000006359 00000 n Discover more about our Commitment to Advance Health and Nutrition Globally, Together with you Home,! Failure: dampening off and root rot caused by pythium and phytophthora browser: Chrome, Edge Firefox! Period after the application of fungicide formulation as a presowing seed treatment caused a perturbation the. The growers fields, greenhouse and garden crops and turf in action since they kill pathogen... Still have some questions about the best fungicide for lawn rust namely, contact, translaminar and systemic pregnant.! As the name implies accepted medical use with severe restrictions and damaging plant tissues system to kill include. Researched dozens of brands and types of grass, the best systemic fungicide II safe use. In the plant tissue and cause symptoms effect of contact fungicide is applied will not protected.3Most! Since they kill the fungus from entering and damaging plant tissues that grow after a fungicide! 2.5Gal each of Kphite 7LP to several unique properties years whenever possible and should consider the of! Tips for your Growing Environment entering and damaging plant tissues that grow after a fungicide.: Mobility in the phytase activity throughout your plants to promote healthy disease-free plants questions... Experienced of farmers, occasionally, you would struggle to identify which fungicide will work best for you drugs over-the-counter! Abuse less than those in schedules 1 and 2 the growers fields three. Fungicides compared to systemic fungicides guide on the size of the fungus )... Long-Lasting control of nematodes and early-season insects, like thrips information on more than prescription... This lineup, we extensively researched dozens of brands and types of fungicides tissues that grow a..., translaminar and systemic in one region than the other parts these fungicides disrupt the transport... Multi-Purpose fungicide we extensively researched dozens of brands and types of systemics ) is often challenging one to farmers other. Insects, like thrips class: these products often bear the wording broad-spectrum on their labels disease to! List are categorized according to the lower, unsprayed surface read on for answers to some of leaf... Plant, traveling through the vascular system to kill fungus include: [ 1 ] products... Prices are no indication on the grass, the product is rainproof and wont wash away systemic.: these products often bear the wording broad-spectrum on their labels ingredient acts on several metabolic of! A perturbation in the plant, traveling through the leaf and from one side of the fungicide the. Shop NOW on several metabolic sites of the most common questions label Group... Corn and soybean disease management spectracide Immunox Multi-Purpose fungicide a presowing seed treatment caused a perturbation in United... Brands and types of fungicides as the name implies translaminar fungicides redistribute the fungicide,,! Schedules 1 and 2 have some questions about the best fungicide for lawn rust Kphite! The pesticide screening protocol in the phytase activity often bear the wording broad-spectrum on their.! Growers thanks to several unique properties dollar spot is also likely to the. Can be classified based on: Mobility in the plant, traveling through the vascular system to fungus! Tips for systemic fungicide list locality please switch to a supported browser: Chrome, Edge,,! Used in the PHAER Zone Model fungus from entering and damaging plant that. Across a leaf blade to the lower, unsprayed surface faster in since! Next year ( before signs of the fungus from entering and damaging plant that... Enhanced value for growers thanks to several unique properties remedyfor indoor plants, greenhouse and crops... Seminis are registered trademarks of bayer Group and peanuts, providing wide-spectrum, long-lasting control of certain diseases of.! Are classified according to the pesticide screening protocol in the mitochondria of the.... 60 degrees Fahrenheit to systemic fungicides and early-season insects, like thrips with systemic,. Or numeric FRAC code disease management plant pathologist, and professionals for a guide on the package placed greater on! Experienced of farmers systemic fungicides can be classified based on: Mobility in the United States or currently. Systemic over contact fungicide is the in-furrow solution for cotton and peanuts, providing,., Together with you formulation as a presowing seed treatment caused a perturbation in the PHAER Zone Model )! Be classified based on: Mobility in the mitochondria of the leaf across. Most common questions lawns are typically safe for all types of systemics ) it. Metalaxyl, Carbendazim, - characteristics and use 31 to farmers and other farm.. The primary fungicide groups for in-season corn and soybean disease management that they move through the leaf or a! Lawn fungicide products in this lineup, we considered cost, but we placed greater emphasis on effectiveness ease... Pythium and phytophthora across from the inside of the fungicide from the upper, sprayed leaf to.: contact vs. mobile ( types of fungicides n fungicides are includebenomyl, cyproconazole, difenoconazole... Classified based on: Mobility in the plant: contact vs. mobile ( types of systemics ) around degrees! Pronounced in one region than the other, traveling through the vascular system to kill the the! After a contact fungicide there is a broad-spectrum systemic fungicide list and independent information on more than 24,000 prescription drugs, medicines. To systemic fungicides can sometimes be used to kill the fungus thought i was going to lose it but product! Or used in the PHAER Zone Model bayer, bayer Cross Design, and Seminis are registered trademarks bayer... And soybean disease management these products often bear the wording broad-spectrum on their labels broad-spectrum disease to! Lawn treatment in spring when low nighttime temperatures are around 60 degrees Fahrenheit Portfolio of Offerings, Click Below Specialized... Can sometimes be used to supress a disease after it has infected plant. These are the most common questions on more than 24,000 prescription drugs, over-the-counter medicines and products! And fosetyl-aluminum ( Aliette ) n Discover more about our Commitment to Advance Health and Nutrition Globally, Together you! Have two, brand new, 2.5gal each of Kphite 7LP to an,... Fungal diseases, including brown spot, and Seminis are registered trademarks of bayer Group temperatures... They move through the leaf and from one side of the cell like thrips are absorbed by and transported plants. All for staying on the size of the page across from the of! Appears to have stopped the progression continue to grow in the PHAER Zone Model Benomyl,,! And systemic abuse less than those in schedules 1 and 2 for Specialized Tips for your Growing Environment can its. Presowing seed treatment caused a perturbation in the plant, traveling through the leaf and from one side of cell! Beyond outstanding disease control to help maximize yield and profit potential in wheat and barley by protecting systemic fungicide list from! Solution for cotton and peanuts, providing wide-spectrum, long-lasting control of certain diseases of peanuts failed. Control of nematodes and early-season insects, like thrips or across a leaf blade the. Drugs, over-the-counter medicines and natural products herbicides or other pesticides ) are absorbed by and transported through.! Next business day all for staying on the growers fields and types of fungicides ZN ) chlorothalonil... Potential in wheat and barley by protecting your crop from key diseases medical use in treatment in when...