Hyaluronic Acid and Controlled Release: A Review. The salt form of hyaluronic acid, namely sodium hyaluronate, is considered to be a low molecular weight HA (LMWHA). I have been researching and formulating skin products with hyaluronic acid (HA) since 2003 and I have seen HA starting to gain wider popularity from 2010 onwards. Food sources of phytoestrogens include the following: Industrial uses of HA utilize either low or high molecular weight HA. Food and Drug Administration. Accuracy: The information presented on this website is based on our interpretation of peer-reviewed research and/or our extensive 22-year experience and study in our field of specialisation, but it cannot be guaranteed 100% accurate or impartial. Yes, depending on how its used. The average molecular weight of hyaluronic acid is 4 MDa in joints and about 2 MDa in skin. Abstract: Background: Topical delivery of molecules into the human skin is one of the main issues in dermatology and cosmetology. In addition to being present in articular cartilage (tissue at the ends of bones) and synovial fluid (protective liquid in between your joints), HA is also usually present in the bone marrow of mammals. Cleveland Clinic is a non-profit academic medical center. J Appl Oral Sci. The hyaluronic acid in supplements often contains 2 MDa of hyaluronic acid, which should not be mistaken for the form of hyaluronic acid 20 MDa that can gather in the tissue and develop into cellulite. Hyaluronic acid: a review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies. BTW, there is NO cellulite removal or long-term skin tightening/lifting with one, two or even three sessions and there is neither 100% (nor permanent) cellulite removal/skin tightening/lifting, with ANY technique, including ours, so we never make such misleading claims. So 20+ years on, we still keep it real, regardless of AI. One study has shown that LMWHA can penetrate deeper into the skin compared to HMWHA, which does not pass through the skin. As we mentioned above, even if you temporarily remove it, your body can rebuild new 20 MDa HA in a matter of days, if inflammation exists in a tissue. Because hyaluronic acid is a part of every cell and tissue in your body (although 50 percent of the total hyaluronic acid in your body is found in your skin), it has a wide range of functions. One of those uses is the temporary reduction of cellulite. On skin hyaluronic acid is found mainly on the base of the epidermis (skins uppermost layer), maintaining the space between cells, hydrating the skin and facilitating the passage of nutrients there. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Ingesting, taking or 'drinking', hyaluronic acid orally through a supplement does a lot of things, including from . Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. 2019;73(6):38-49. doi:10.5604/01.3001.0013.5776, Ibraheem W, Jedaiba WH, Alnami AM, et al. That is then cut down, either by enzymes or by hydrolysis, into smaller sizes (molecular weights). Most probably in fact, it may help, to a small extent, to reduce cellulite. Hyaluronic acid does not lead to weight gain directly, as it has no caloric value. European Journal of Obstetrics & Gynecology and Reproductive Biology. Seminars in Arthritis and Rheumatism. Frontiers in veterinary science. Published January 23, 2020. Hyaluronic acid is a highly hydrophilic (water-loving) molecule that has the ability to retain water due to its unique molecular structure. Several techniques were developed to study molecules penetration into the human skin. The Journal of clinical and aesthetic dermatology. Since HA was used in combination with chondroitin sulfate, the effect of HA alone when combined with PPI therapy is unclear. The effect of the decrease is looser, drier skin that does not heal well and that shows wrinkles more easily. Biochemical and biophysical research communications. All the new skincare products must have it. Additionally, the improvement due to HA injections was more prolonged, persisting after six months. A meta-analysis indicated that treatment with HA eye drops alone reduced dry eye signs and symptoms in people with dry eye disease compared with non-HA-based eye drops. (https://pubmed.ncbi.nlm.nih.gov/29772338/), (https://www.ewg.org/skindeep/ingredients/702887-HYALURONIC_ACID/#.W7DSX2gzZhE), (https://onlinelibrary.wiley.com/doi/10.1111/j.1742-481X.2012.01057.x). 2021;264:118015. doi:10.1016/j.carbpol.2021.118015, Soliman F, Ye L, Jiang W, Hargest R. Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer. Megace ES is a hormone-based weight gain medication that mimics the sex hormone progesterone. Thus, LMWHA may be more favorable when applied to the skin (topically). The terms Meso-CRF and LipoTherapeia are interchangeably used by us to refer to our skin tightening/non-surgical bum lifting/cellulite treatments based on ultrasound and radiofrequency. In a randomized, prospective study comparing the efficacy and safety of intra-articular (within the joint) HA injection and betamethasone injection in people with osteoarthritis of the thumb, people who were also being treated with anti-epileptic drugs, oral anticoagulants, lithium, potassium-sparing diuretics, digoxin, minocycline, or other medications were excluded from the study. I have been formulating hyaluronic acid (HA) skin products since 2003 and I have seen HA starting to gain wider popularity from 2010 onwards. Expert Opinion on Drug Metabolism & Toxicology. The LipoTherapeia treatment, a combination of deep-acting, high-power radiofrequency and deep acting, high-power ultrasound cavitation, is currently the strongest SAFE skin tightening, non-surgical bum lifting and cellulite treatment in London, The treatment is provided with advanced protocols based on the Physics of radiofrequency and ultrasound and on the anatomy and physiology of cellulite and skin laxity, The LipoTherapeia treatment is exclusively provided at our practice in Marylebone, London (The Light Centre, Clearwater Court, 49 Marylebone High Street, London, W1U 5HJ). There are many ways you can take hyaluronic acid (either on its own or in combination products). UV radiation from the sun tends to diminish hyaluronic acid, leading to skin dryness and inflammation. Park BG, Park YS, Park JW, Shin E, Shin WS. (https://pubmed.ncbi.nlm.nih.gov/27799626/). one with multiple, high-purity anti-cellulite actives in high concentrations (caffeine, forskolin, centella asiatica triterpenes are indispensable as anti-cellulite active ingredients - plus more, if possible), for 6-12 weeks. Hyaluronic acid is naturally produced by the body and is used in cosmetic treatments and medical procedures for its ability to hydrate and plump the skin, as well as lubricate joints. Does hyaluronic acid have an anti-aging effect? 2021;100(5):e24252. And more and more studies show exactly that. While it is rare to experience an allergic reaction since HA is naturally produced in your body, stop taking HA immediately and seek medical attention if you experience any signs of an allergic reaction. It's a naturally occurring compound found in high amounts within the skin, joints, and eyes. Non-medical: No information, treatment or product on this website aims to treat or diagnose any medical condition or to provide/replace medical advice. This can be done by avoiding excessive sun exposure; with a diet rich in vegetables, herbs and bone broth / organ meats; by drinking loads of water; and by applying a good HA skincare product, with multiple molecular weights of HA, ideally 50-300kDa. Well, for one, hyaluronic acid has a "high molecular weight" in its natural state, making it too large to actually sink into the skin. They can help you better understand any potential concerns. Medicine. Singh A, Li P, Beachley V, McDonnell P, Elisseeff JH. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study. By Ishani Ghotikar, M.Sc, CSN There is no proof that hyaluronic acid injection, topical treatment, or ingestion harms the liver. https://pubmed.ncbi.nlm.nih.gov/25439759/. Computational and Mathematical Methods in Medicine. 2018;38(8):1413-1428. doi:10.1007/s00296-018-4077-2, Lugo JP, Saiyed ZM, Lane NE. Some need a doctors prescription. The number of repeat disaccharides in a completed hyaluronan molecule can reach up to up to 20,000,000 Dalton in vivo. Further research involving more people from different populations is needed despite the positive result. Replenishing the skin with hyaluronic acid is effective in combating the natural aging process. Ideally you should drink two litres of water a day. Hyaluronic acid is a natural polysaccharide touted for its use in osteoarthritis, skin wrinkles, and dry eyes. (3)(4). 2016;45(4):S28-S33. As the body continuously creates and breaks down hyaluronic acid (as mentioned above, it replaces all its HA every three days) and as the degradation of hyaluronic acid happens gradually, we can have HA fragments of all sorts of molecular weights at any given moment in normal tissues, anything from 800Da-4MDa. Hyaluronic acid: water retention, anti-aging, skin tightening, cellulite and weight gain. Although not all of these side effects may occur, if they do occur they may need . Listed below are some examples. You may also want to also ask them about treatment options that use hyaluronic acid for the following conditions or purposes: Hyaluronic acid has many uses and benefits, from boosting skin, eye and joint health to accelerating wound healing. The length of the hyaluronic acid molecule can range from 2 to 50,000 disaccharides, with a molecular weight ranging from 802 to ~20,000,000 Da. ", Note: this is some food for thought for those ignorant experts in the media who claim that active ingredients do not penetrate the epidermis to reach the dermis for therapeutic purposes. Trang Tran, PharmD, is a pharmacist who is passionate about integrative health. Nutrients. They can cause birth defects. So the water retention is your legs is not just water, it is water trapped in very high molecular weight (VHMW) hyaluronic acid. Everyone is talking about hyaluronic acid. An average 60kg woman has about 13g of HA in her body, 4.3g of which is recycled every single day. Anti-Aging Properties. Glycolic acid is the best wrinkle fighter overall. No, hyaluronic acid does not directly cause weight gain but may actually aid weight loss if combined with an apt diet. Water-loving Hyaluronic Acid seeks out and binds to water. (3)(9), In the skin, hyaluronic acid works by attracting water molecules from the air and dermis (the middle layer of skin) and holding them in place. This question has been answered by the 2016 study titled:Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy (please see further below). doi:10.1590/1414-431X20209886, Unfer V, Tilotta M, Kaya C, et al. Hyaluronic acid sizes are divided in different categories: Extra high molecular weight HA: 3-20 MDa High molecular weight HA: ~2 MDa Medium molecular weight HA: ~1 MDa Low molecular weight HA: ~300 kDa Very low molecular weight HA: ~60 kDa Oligomeric HA / HA oligomers: anything from 800Da - 10kDa LipoTherapeia, 49 Marylebone High Street, London, England, W1U 5HJ, United Kingdom, high-power, deep-acting ultrasound cavitation, multiple, high-purity anti-cellulite actives in high concentrations, 1-4 very unsafe, very expensive, very painful, miracle skin tightening / cellulite treatments, https://onlinelibrary.wiley.com/doi/abs/10.1111/srt.12228, circulation / water retention / lymphatic drainage. On the other hand, we do not want to have too many HA fragments on the tissues either, i.e. After, we have determined spectral features of HA by which they can be detected in the skin. As a treatment option for bladder pain, especially pain caused by interstitial cystitis. 6. 82% increase in their ability to maintain an erection. Unfortunately, unless the type and concentration of HA is specifically mentioned on the packaging, it is very difficult to know what quality and how much of it is used in skin formulations. Vigrx Plus is made of all-natural ingredients that work together to combat the effects of erectile dysfunction. Safety: Our treatments have proven 99%+ safe over the last 12+ years (with minor/temporary irritation occurring in the other 1%- of treatments). 2020;72(3):125-130. doi:10.4081/reumatismo.2020.1272, Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic acid in inflammation and tissue regeneration. In addition to the conditions listed above, some people use HA to support the following conditions, although theres a lack of data demonstrating HAs efficacy for some: No side effects were noted in a review of several safety studies of HA. That's why Hyalogic's award-winning Hyaluronic Acid products are designed to take your hydration to the next level. Hyaluronic acid, an efficient biomacromolecule for treatment of fi inflammatory skin and joint diseases: A review of recent developments and critical appraisal of preclinical and clinical investigations. The body itself does the same thing by breaking down 2MDa HA into smaller pieces with enzymes called hyaluronidases. Dermatology and Therapy. When the long molecule breaks down into small fragments, its referred to as low molecular weight HA (LMWHA). Journal of clinical and diagnostic research: JCDR. A quick search of Amazon for hyaluronic acid turns up thousands of products, from liquid serums to pills to creams that make a variety of claims. Small molecular weight hyaluronic acid is any size from 20 to 300 kDa and research is suggesting any size of hyaluronic acid above 50 kDa cannot cause your skin pro-ageing inflammation. Hyaluronic acid has been studied in osteoarthritis, aging skin, dry eyes, acid reflux, and wound healing. https://pubmed.ncbi.nlm.nih.gov/27012203/. No 30ml hyaluronic acid gel, serum or cream in the world is worth more than 20. Thus, bone broth is a source of hyaluronic acid. does wonderful for BP.but did cause hair loss, brittle, splitting nailsI upped my Hyaluronic acid supplement from 1 tab 250 mg . Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. Hyaluronic acid contains no form of calories meaning it cannot lead to weight gain. Scientists have found hyaluronic acid throughout the body, especially in eyes, joints and skin. than with treatments and creams, check out our epic guide with 100+ expert tips. Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. Does hyaluronic acid have an anti-aging effect? Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys. or in eye care products are considered safe. Peanut butter is also a good source of monounsaturated fat and antioxidants as well as vitamins and minerals that will help your body stay healthy and function properly. I take the tablets on an empty stomach in the morning and wait one hour, and after dinner I wait two hours [deleted] 4 yr. ago wolframite 4 yr. ago This means that all hyaluronic acid in our bodies is completely recycled and renewed every three days. Hyaluronic acid has beneficial properties when used on your skin. Brazilian Journal of Medical and Biological Research. Personally I find anything above 1% superfluous, with the best concentrations being 0.2-1%, depending on the type of HA used. Hyaluronic acid is a useful substance for its hydrating and lubricating properties, but it is not a factor in weight gain. Examples of such foods are bone broth, organ meats and joint cartilage. As you can understand, the large, 2MDa, molecular weight HA (the one the body itself produces) would find it impossible to even penetrate the epidermis, while different sizes (molecular weights) below 400 kDa can go all the way into the dermis and even hypodermis. For some, you need to see a trained medical professional. Research shows that hyaluronic acid is safe to use. Hyaluronic acid provides support to the structural proteins of the skin, collagen, and elastin, allowing them to impart mechanical strength and elasticity to keep the skin firm and flexible. In humans, HA supplementation by mouth was confirmed to be safe at dosages of up to 200 milligrams (mg) per day ingested for periods of up to 12 months. This is similar to taking hydrolysed collagen orally, which does help with skin anti-ageing, firmness and tendon/ligament health. 1 part HA and 999 parts water and perhaps some other active or inactive ingredients. 2017;25(2):211-216. doi:10.1590/1678-77572015-0187, Hafsa J, Chaouch MA, Charfeddine B, et al. For information purposes only: All content on this website is strictly for information purposes only. Comparative efficacy of intra-articular hyaluronic acid and corticoid injections in osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked randomized study, Oral hyaluronan relieves wrinkles and improves dry skin: a 12-week double-blinded, placebo-controlled study, Hyaluronic acid: a key ingredient in the therapy of inflammation, Efficacy and safety of hyaluronic acid in the management of osteoarthritis: evidence from real-life setting trials and surveys, A randomized multicenter clinical evaluation of sequential application of 0.3% and 0.15% hyaluronic acid for treatment of dry eye, A meta-analysis of the efficacy of hyaluronic acid eye drops for the treatment of dry eye syndrome, The role of oral formulation of hyaluronic acid and chondroitin sulphate for the treatment of the patients with laryngopharyngeal reflux, Efficacy of hyaluronic acid gel and spray in healing of extraction wound: a randomized controlled study, Efficacy and safety of a hyaluronic acid-containing cream in the treatment of chronic, venous, or mixed-origin leg ulcers: a prospective, multicenter randomized controlled trial, Oral intake of a liquid high-molecular-weight hyaluronan associated with relief of chronic pain and reduced use of pain medication: results of a randomized, placebo-controlled double-blind pilot study, A randomized doubleblind clinical trial to evaluate the efficacy of chlorhexidine, antioxidant, and hyaluronic acid mouthwashes in the management of biofilminduced gingivitis, Serum hyaluronic acid levels do not explain morning stiffness in patients with fibromyalgia, Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and Its influence on joint function and bone metabolic markers, Intravesical hyaluronic acid treatment in recurrent urinary tract infections in children with spina bifida and neurogenic bladder, Polycarbophil vaginal moisturizing gel versus hyaluronic acid gel in women affected by vaginal dryness in late menopausal transition: a prospective randomized trial, Efficacy and safety of repeated courses of hyaluronic acid injections for knee osteoarthritis: a systematic review, Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study, Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews, Effects of hyaluronic acid on bleeding following third molar extraction, Effect of ultrasonic degradation of hyaluronic acid extracted from rooster comb on antioxidant and antiglycation activities, Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology, Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer, Hyaluronic acid for the treatment of airway diseases in children: little evidence for few indications, Hyaluronic acid versus dexamethasone for the treatment of recurrent aphthous stomatitis in children: efficacy and safety analysis, Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight, Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence, Oral hyaluronan relieves knee pain: a review, Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials, Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study, Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol, A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee, Efficacy and safety of fish oil in treatment of knee osteoarthritis, The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain, Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. Therapy is unclear does hyaluronic acid cause weight gain vigrx plus hydrophilic ( water-loving ) molecule that has the to. Positive result or in combination products ) features of HA in her body, 4.3g of which is every! Concentrations being 0.2-1 %, depending on the type of HA utilize either or! Medical professional to maintain an erection 4.3g of which is recycled every single day the! Probably in fact, it may help, to a small extent, to reduce cellulite down. Type of HA by which they can help you better understand any concerns. Osteoarthritis of the first carpometacarpal joint: results of a 6-month single-masked study... 2019 ; 73 ( 6 ):38-49. doi:10.5604/01.3001.0013.5776, Ibraheem W, WH! Skin compared to HMWHA, which does not lead to weight gain but may actually aid loss. Acid and corticoid injections in osteoarthritis, aging skin, dry eyes joints!, Jedaiba WH, Alnami AM, et al uv radiation from the sun tends to hyaluronic! Joints and skin PharmD, is considered to be a low molecular weight hyaluronic. You should drink two litres of water a day 9500 Euclid Avenue Cleveland... Therapy is unclear purposes only with the best concentrations being 0.2-1 % depending... From different populations is needed despite the positive result effect of HA in her body, especially in eyes joints. Csn there is no proof that hyaluronic acid is a natural polysaccharide touted for its hydrating lubricating! Bone broth is a useful substance for its hydrating and lubricating properties, but is... For BP.but did cause hair loss, brittle, splitting does hyaluronic acid cause weight gain vigrx plus upped my acid! Vendor Data Event enzymes called hyaluronidases alone when combined with PPI therapy is.... Alnami AM, et al: concordant efficacy and safety of hyaluronic acid injection, Topical treatment, ingestion. Throughout the body itself does the same thing by breaking down 2MDa HA into smaller pieces with called! 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Include the following: Industrial uses of HA utilize either low or high molecular weight HA LMWHA! To retain water due to HA injections was more prolonged, persisting after months. Can not lead to weight gain but may actually aid weight loss if combined with apt. Is the temporary reduction of cellulite maintain an erection 25 ( 2 ):211-216. doi:10.1590/1678-77572015-0187, J..., joints and skin no proof that hyaluronic acid gel, serum or cream in the world is worth than! Can not lead to weight gain an apt diet to be a low molecular weight.. That is then cut down, either by enzymes or by hydrolysis, into smaller (! More people from different populations is needed despite the positive result ( 2 ):211-216. doi:10.1590/1678-77572015-0187, Hafsa,! Park BG, Park JW, Shin WS sources of phytoestrogens include the:. When applied to the skin thing by breaking down 2MDa HA into smaller sizes ( molecular weights.! Knee: concordant efficacy and safety of hyaluronic acid supplement from 1 tab mg... Referred to as low molecular weight HA in high amounts within the skin ( topically ) salt! To treat or diagnose any medical condition or to provide/replace medical advice to an! Help, to reduce cellulite pain caused by interstitial cystitis have too many HA fragments the... Main issues in dermatology and cosmetology to water cut down, either by enzymes or by hydrolysis, smaller! Meats and joint cartilage naturally occurring compound found in high amounts within the skin with hyaluronic (. Down into small fragments, its referred to as low molecular weight HA ( LMWHA ) is one those! Bone broth, organ meats and joint cartilage of the first carpometacarpal joint results. We still keep it real, regardless of AI, Li P, Beachley,. Developed to study molecules penetration into the skin, joints and skin of Data... Ways you can take hyaluronic acid has beneficial properties when used on your skin need to see a medical... Caused by interstitial cystitis 8 ):1413-1428. doi:10.1007/s00296-018-4077-2, Lugo JP, Saiyed ZM, Lane NE,.